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Immunoassay of insulin-like growth factor-binding protein-3 (IGFBP-3): new means to quantifying IGFBP-3 proteolysis

C.et al (2018)

5-amino-1mq, or 5-amino-1-methylquinolinium, is a synthetic small molecule compound that targets a specific enzyme involved in metabolic regulation

Endocrine, 15 (1), 9195

The investigators reported that NNMT knockdown produced protection from diet-induced obesity and increased adipocyte energy expenditure, establishing the genetic precedent for the 5-Amino-1MQ pharmacological program